Endocrine Abstracts

Introduction: Thionamides are first line treatment in the management of thyrotoxicosis; nevertheless several weeks of treatment is needed before euthyroidism is restored. This delayed and gradual action makes thionamides insufficient as sole treatment when acute control of the hyperthyroid status is mandatory, hence the need for potent yet rapid acting adjuvant antithyroid agent. Lithium is a monovalent cation that inhibits thyroid iodine uptake and hormone release with maximu...

A 39-year-old man was referred to our department with an incidental finding of low blood glucose. He had presented to rheumatology with non-traumatic left knee pain and swelling. He had a longstanding history of obstructive sleep apnoea and hiatus hernia. He had not been taking any medications. Examination was unremarkable apart from tender left knee with an effusion. A diagnosis of reactive arthritis was made. An incidental finding of low blood glucose (2.7 mmol/l-normal 3.4&...

Our goal is to better understand the molecular and cellular nature of paediatric combined pituitary hormone deficiency diseases in order to facilitate improved diagnosis, treatment, and family counselling. LIM-homeodomain transcription factors regulate many aspects of development and mutations in the genes that encode these regulatory proteins are associated with several diseases. The LHX3 LIM-homeodomain protein is critical for pituitary gland organogenesis and some nervous s...

Background: Recent studies show that Infliximab (IFX), an antibody against tumour necrosis factor α (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13 M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months be...

Background: Recent studies show that infliximab (IFX), an antibody against tumour necrosis factorα (TNFα), may improve growth in children with Crohn’s disease (CD). These studies have not adequately addressed the concomitant factors such as medication, nutrition and puberty that may also improve growth.Methods: Retrospective study of 22 children (13M) with CD, median age at start of IFX 13.2 years (7.4, 16.1) with auxology at 6 months befo...

INTRODUCTION: Although thyrotoxicosis involving the musculoskeletal system is well described, classically presenting with proximal myopathy, arthralgia and osteopenia, an acute synovio-arthritis is extremely rare. There are only two published case reports, which have features distinct from Rheumatoid, Sjogren's and Psoriatic arthropathy.CASE REPORT: A 21-year-old lady presented with a 2-month history of symptoms and signs consistent with thyrotoxicosis....

Background: Puberty is understood to be commonly effected in adolescents with Crohn’s Disease (CD) and ulcerative colitis (UC). However, the extent of this effect and related problems with growth, have rarely been quantified.Objective: To determine the impact of CD and UC on pubertal growth.Methods: Retrospective study of 148 children with IBD (casenotes available, 135) who fulfilled the criteria for describing growth spurt pa...

Aims: To compare glycaemic control and weight gain in children with type 1 diabetes changing from twice daily premixed insulin to multiple daily injections (MDI) with either insulin glargine or insulin detemir.Methods: A retrospective study of 41 consecutive children and adolescents with type 1 diabetes, changed to MDI between January 2005 and April 2007, with outcome measures of HbA1C change and body mass index SDS (BMI-SDS) change after 12 months of MD...